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Clinical Research

Analysis of maternal biosignals using deep learning

Background

Preterm birth (when a baby is born earlier than expected) and stillbirth (when a baby dies before being born) are highly complex conditions that are still far from fully understood. Maternal age, sexually transmitted infections and fetal genetic abnormalities have all been identified as contributing factors, yet a large proportion of cases remain unexplained.

Today, against a backdrop of social change such as the rising age of pregnancy, there is growing concern that preterm birth is increasing. Progress in reducing stillbirth has likewise stagnated worldwide, making it a serious social issue.

Research Overview

In this study, we link biological signals acquired from the mother with clinical information on both the mother and the fetus during pregnancy, and use deep learning to analyze the relationships between them.

This allows us to obtain far more detailed insight into the condition of the fetus during pregnancy, which has long remained a black box.

About the study results

Findings from this study will be presented at academic conferences and published in peer-reviewed journals, and will also be disclosed on this page.

Contact

If you are a participant in this study and have any questions, please contact us using the form indicated in the informed consent form you received.

Please note that, in order to protect personal information, we are unable to respond to inquiries regarding this clinical study that are submitted through the general “Contact” page of this website. We appreciate your understanding.

References

1. Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med. 2002 Jan;346(3):149–57.

2. Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med. 2008 Jul;359(3):262–73.

3. Born too soon: decade of action on preterm birth [Internet]. [cited 2024 Mar 27]. Available from: https://www.who.int/publications-detail-redirect/9789240073890

4. Risnes K, Bilsteen JF, Brown P, Pulakka A, Andersen AMN, Opdahl S, et al. Mortality Among Young Adults Born Preterm and Early Term in 4 Nordic Nations. JAMA Netw Open. 2021 Jan;4(1):e2032779.

5. Haruyama R, Gilmour S, Ota E, Abe SK, Rahman MM, Nomura S, et al. Causes and risk factors for singleton stillbirth in Japan: Analysis of a nationwide perinatal database, 2013–2014. Sci Rep. 2018 Mar 7;8(1):4117.

6. Stillbirth Collaborative Research Network Writing Group. Causes of death among stillbirths. JAMA. 2011 Dec;306(22):2459–68.

7. Fretts RC, Boyd ME, Usher RH, Usher HA. The changing pattern of fetal death, 1961-1988. Obstet Gynecol. 1992 Jan;79(1):35–9.

8. Iams JD, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. What have we learned about uterine contractions and preterm birth? The HUAM Prediction Study. Semin Perinatol. 2003 Jun;27(3):204–11.

9. WHO multicountry survey on maternal and newborn health 2010-2012 [Internet]. [cited 2025 Feb 28]. Available from: https://www.who.int/news/item/08-01-2016-who-multicountry-survey-on-maternal-and-newborn-health-2010-2012

10. Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita ATN, Reddy UM, Saade GR, et al. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med. 2016 Apr;374(14):1311–20.

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