{"id":343,"date":"2023-11-20T15:26:33","date_gmt":"2023-11-20T06:26:33","guid":{"rendered":"http:\/\/nonat.co.jp\/en\/?page_id=343"},"modified":"2026-03-15T06:35:46","modified_gmt":"2026-03-14T21:35:46","slug":"clinical-research","status":"publish","type":"page","link":"https:\/\/nonat.co.jp\/en\/clinical-research\/","title":{"rendered":"Clinical Research"},"content":{"rendered":"\n

AI-Driven Maternal Biometric Analysis for Pregnant Women<\/h2>\n\n\n\n

Background<\/h4>\n\n\n\n
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Preterm birth and stillbirth are major social and public health challenges worldwide. While a range of factors\u2014such as maternal age, infectious diseases, and genetic abnormalities\u2014have been identified as potential causes, many aspects remain unclear.
Amid broader social changes, particularly the rise in pregnancies at advanced maternal age, the risk of preterm birth is increasing.
In 2020, the World Health Organization (WHO) sounded the alarm on the state of preterm birth, describing its global burden as a \u201csilent emergency,\u201d noting that rates have not improved in decades.
The impact of preterm birth and stillbirth extends beyond individuals to society at large. The costs associated with tertiary care and subsequent lifelong support are substantial, with the United States spending more than USD 20 billion annually on the management of preterm birth and the United Kingdom spending approximately GBP 2.5 billion.<\/p>\n<\/div>\n\n\n\n

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Research Overview<\/h4>\n\n\n\n

Guided by medical and physiological perspectives, we hypothesize that there is a mapping between multimodal maternal biometric data and the intrauterine environment\u2014and that these relationships can be modeled and inferred using deep learning.
Since our founding, we have conducted multiple research projects and completed several proofs of concept (PoCs). Building on the knowledge gained along the way, we are currently developing a foundation model for pregnancy.
As a future application of this model, we are in discussions with a national university to conduct clinical research that explores the potential for early intervention in high-risk cases such as preterm birth and stillbirth.<\/p>\n\n\n\n

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Research Outcomes<\/h4>\n\n\n\n

At the 2025 Annual Congress of the Japan Society of Obstetrics and Gynecology (JSOG), we presented our findings to medical experts. We are currently preparing a manuscript for submission to a peer-reviewed journal.
We will update this page as new results become available.<\/p>\n\n\n\n

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Contact<\/h4>\n\n\n\n

If you are a study participant and have any questions, please contact us via the form specified in the informed consent document.
To protect participants\u2019 personal information, we are unable to respond to individual inquiries about this clinical research submitted through the website\u2019s general \u201cContact Us\u201d form. We appreciate your understanding. For details on how we handle personal information, please refer to our privacy policy at the link below.<\/p>\n\n\n\n

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References<\/strong><\/p>\n\n\n\n

1. Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med. 2002 Jan;346(3):149\u201357.<\/p>\n

2. Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med. 2008 Jul;359(3):262\u201373.<\/p>\n

3. Born too soon: decade of action on preterm birth [Internet]. [cited 2024 Mar 27]. Available from: https:\/\/www.who.int\/publications-detail-redirect\/9789240073890<\/p>\n

4. Risnes K, Bilsteen JF, Brown P, Pulakka A, Andersen AMN, Opdahl S, et al. Mortality Among Young Adults Born Preterm and Early Term in 4 Nordic Nations. JAMA Netw Open. 2021 Jan;4(1):e2032779.<\/p>\n

5. Haruyama R, Gilmour S, Ota E, Abe SK, Rahman MM, Nomura S, et al. Causes and risk factors for singleton stillbirth in Japan: Analysis of a nationwide perinatal database, 2013\u20132014. Sci Rep. 2018 Mar 7;8(1):4117.<\/p>\n

6. Stillbirth Collaborative Research Network Writing Group. Causes of death among stillbirths. JAMA. 2011 Dec;306(22):2459\u201368.<\/p>\n

7. Fretts RC, Boyd ME, Usher RH, Usher HA. The changing pattern of fetal death, 1961-1988. Obstet Gynecol. 1992 Jan;79(1):35\u20139.<\/p>\n

8. Iams JD, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. What have we learned about uterine contractions and preterm birth? The HUAM Prediction Study. Semin Perinatol. 2003 Jun;27(3):204\u201311.<\/p>\n

9. WHO multicountry survey on maternal and newborn health 2010-2012 [Internet]. [cited 2025 Feb 28]. Available from: https:\/\/www.who.int\/news\/item\/08-01-2016-who-multicountry-survey-on-maternal-and-newborn-health-2010-2012<\/p>\n

10. Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita ATN, Reddy UM, Saade GR, et al. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med. 2016 Apr;374(14):1311\u201320.<\/p><\/p>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"

AI-Driven Maternal Biometric Analysis for Pregnant Women Background Preterm birth and stillbirth are major social and public health challenges worldwide. While a range of factors\u2014such as maternal age, infectious diseases, and genetic abnormalities\u2014have been identified as potential causes, many aspects remain unclear.Amid broader social changes, particularly the rise in pregnancies at advanced maternal age, the risk of preterm birth is increasing.In 2020, the World Health Organization (WHO) sounded the alarm on the state of preterm birth, describing its global burden as a \u201csilent emergency,\u201d noting that rates have not improved in decades.The impact of preterm birth and stillbirth extends beyond individuals to society at large. The costs associated with tertiary […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"swell_btn_cv_data":"","slim_seo":{"title":"Clinical Research | nonat Inc.","description":"AI-Driven Maternal Biometric Analysis for Pregnant Women Background Preterm birth and stillbirth are major social and public health challenges worldwide. While"},"footnotes":""},"class_list":["post-343","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/pages\/343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/comments?post=343"}],"version-history":[{"count":24,"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/pages\/343\/revisions"}],"predecessor-version":[{"id":2286,"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/pages\/343\/revisions\/2286"}],"wp:attachment":[{"href":"https:\/\/nonat.co.jp\/en\/wp-json\/wp\/v2\/media?parent=343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}